Chronic ocular surface pain (COSP) may be defined as a feeling of pain, perceived as originating from the ocular surface, that persists for >3 months. COSP is a complex multifactorial condition associated with several risk factors that may significantly interfere with an individual's daily activities, resulting in poor quality of life (QoL). COSP is also likely to have a high burden on patients with substantial implications on global healthcare costs. While patients may use varied terminology to describe symptoms of COSP, any ocular surface damage in the ocular sensory apparatus (nociceptive, neuropathic, inflammatory, or combination thereof) resulting in low tear production, chronic inflammation, or nerve abnormalities (functional and/or morphological), is typically associated with COSP. Considering the heterogeneity of this condition, it is highly recommended that advanced multimodal diagnostic tools are utilized to help discern the nociceptive and neuropathic pain pathways in order to provide targeted treatment and effective clinical management. The current article provides an overview of COSP, including its multifactorial pathophysiology, etiology, prevalence, clinical presentation, impact on QoL, diagnosis, current management, and unmet medical needs.

慢性眼表疼痛 (COSP) 可定义为一种疼痛感，被认为起源于眼表，持续时间 > 3 个月。COSP 是一种复杂的多因素疾病，与多种风险因素相关，这些风险因素可能会严重干扰个人的日常活动，从而导致生活质量 (QoL) 不佳。COSP 还可能给患者带来沉重负担，对全球医疗保健成本产生重大影响。虽然患者可能会使用不同的术语来描述 COSP 的症状，但眼部感觉器官中的任何眼表损伤（伤害性、神经性、炎症性或其组合）会导致泪液分泌减少、慢性炎症或神经异常（功能和/或形态学） ), 通常与 COSP 相关联。考虑到这种情况的异质性，强烈建议使用先进的多模式诊断工具来帮助辨别伤害性疼痛和神经性疼痛通路，以便提供有针对性的治疗和有效的临床管理。当前文章概述了 COSP，包括其多因素病理生理学、病因学、患病率、临床表现、对 QoL 的影响、诊断、当前管理和未满足的医疗需求。