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Geranylgeranyl pyrophosphate depletion by statins compromises skeletal muscle insulin sensitivity
Journal of Cachexia, Sarcopenia and Muscle ( IF 9.4 ) Pub Date : 2022-08-12 , DOI: 10.1002/jcsm.13061
Lai Wang 1 , Zuguo Zheng 1 , Lijun Zhu 1 , Lingchang Meng 1 , Hanling Liu 1 , Keke Wang 1 , Jun Chen 1 , Ping Li 1 , Hua Yang 1
Affiliation  

Statins are widely prescribed cholesterol-lowering drugs but have been shown to increase the risk of type 2 diabetes mellitus. However, the molecular mechanisms underlying the diabetogenic effect of statins are still not fully understood.

中文翻译:

他汀类药物耗尽香叶基香叶基焦磷酸盐会损害骨骼肌胰岛素敏感性

他汀类药物是广泛使用的降胆固醇药物,但已被证明会增加患 2 型糖尿病的风险。然而,他汀类药物致糖尿病作用的分子机制仍未完全明了。
更新日期:2022-08-12
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