Lumbar spinal stenosis is a risk factor for the development of dementia: locomotive syndrome and health outcomes in the Aizu cohort study,European Spine Journal

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Lumbar spinal stenosis is a risk factor for the development of dementia: locomotive syndrome and health outcomes in the Aizu cohort study
European Spine Journal ( IF 2.6 ) Pub Date : 2022-08-13 , DOI: 10.1007/s00586-022-07318-4
Hiroshi Kobayashi ₁ , Ryoji Tominaga ₁ , Koji Otani ₁ , Miho Sekiguchi ₁ , Takuya Nikaido ₁ , Kazuyuki Watanabe ₁ , Kinshi Kato ₁ , Shoji Yabuki ₁ , Shin-Ichi Konno ₁

Affiliation

Purpose

It remains unclear whether musculoskeletal diseases are risk factors for dementia development. This prospective cohort study of community-dwelling residents aimed to clarify the impact of lumbar spinal stenosis (LSS) on dementia development.

Methods

We included participants aged ≥ 65 years from the Locomotive Syndrome and Health Outcomes in the Aizu cohort study. LSS was diagnosed using the validated LSS diagnostic support tool. Dementia development between 2008 and 2015 was investigated using official long-term care insurance certification data. We analysed the effects of LSS on dementia development after adjusting for potential confounders, like age, sex, diabetes, depressive symptoms, hip and knee joint osteoarthritis, daily activity, and smoking habit.

Results

We included 1220 patients in the final analysis. The incidence of dementia was significantly higher in the LSS group [48 of 444 (10.8%)] than in the control group [34 of 776 (4.4%)]. Multivariable analysis using multiple imputations revealed that the confidence interval for the adjusted odds ratio of LSS for dementia development was 1.87 (95% confidence interval; 1.14–3.07).

Conclusion

We clarified that LSS is an independent risk factor for dementia development. Our findings suggest the importance of considering the risk of dementia in the decision-making process for the treatment of LSS.

中文翻译：

腰椎管狭窄症是痴呆症发展的危险因素：会津队列研究中的运动综合征和健康结果

目的

目前尚不清楚肌肉骨骼疾病是否是痴呆症发展的危险因素。这项针对社区居民的前瞻性队列研究旨在阐明腰椎管狭窄症 (LSS) 对痴呆症发展的影响。

方法

我们在会津队列研究中纳入了年龄≥ 65 岁的运动综合征和健康结果参与者。使用经过验证的 LSS 诊断支持工具诊断 LSS。使用官方长期护理保险认证数据调查了 2008 年至 2015 年痴呆症的发展情况。在调整了年龄、性别、糖尿病、抑郁症状、髋关节和膝关节骨关节炎、日常活动和吸烟习惯等潜在混杂因素后，我们分析了 LSS 对痴呆发展的影响。

结果

我们在最终分析中纳入了 1220 名患者。LSS 组 [444 人中的 48 人 (10.8%)] 的痴呆发生率显着高于对照组 [776 人中的 34 人 (4.4%)]。使用多重插补的多变量分析显示，针对痴呆发展的 LSS 调整比值比的置信区间为 1.87（95% 置信区间；1.14–3.07）。