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Impact of Seasonal Coronavirus Antibodies on SARS-CoV-2 Vaccine Responses in Solid Organ Transplant Recipients
Clinical Infectious Diseases ( IF 8.2 ) Pub Date : 2022-08-12 , DOI: 10.1093/cid/ciac652 Andrew H Karaba 1 , Weiqiang Zhou 2 , Shuai Li 2 , Tihitina Y Aytenfisu 1 , Trevor S Johnston 1 , Olivia Akinde 3 , Yolanda Eby 3 , Aura T Abedon 4 , Jennifer L Alejo 4 , Caroline X Qin 4 , Elizabeth A Thompson 1 , Jacqueline M Garonzik-Wang 5 , Joel N Blankson 1 , Andrea L Cox 1, 6, 7 , Justin R Bailey 1 , Sabra L Klein 6 , Andrew Pekosz 6 , Dorry L Segev 4, 8 , Aaron A R Tobian 3 , William A Werbel 1
Clinical Infectious Diseases ( IF 8.2 ) Pub Date : 2022-08-12 , DOI: 10.1093/cid/ciac652 Andrew H Karaba 1 , Weiqiang Zhou 2 , Shuai Li 2 , Tihitina Y Aytenfisu 1 , Trevor S Johnston 1 , Olivia Akinde 3 , Yolanda Eby 3 , Aura T Abedon 4 , Jennifer L Alejo 4 , Caroline X Qin 4 , Elizabeth A Thompson 1 , Jacqueline M Garonzik-Wang 5 , Joel N Blankson 1 , Andrea L Cox 1, 6, 7 , Justin R Bailey 1 , Sabra L Klein 6 , Andrew Pekosz 6 , Dorry L Segev 4, 8 , Aaron A R Tobian 3 , William A Werbel 1
Affiliation
Antibody responses to SARS-CoV-2 vaccination are reduced in solid organ transplant recipients (SOTRs). We report that increased levels of pre-existing antibodies to seasonal coronaviruses are associated with decreased antibody response to SARS-CoV-2 vaccination in SOTRs, supporting that antigenic imprinting modulates vaccine responses in this immunosuppressed population.
中文翻译：
季节性冠状病毒抗体对实体器官移植受者 SARS-CoV-2 疫苗反应的影响
实体器官移植受者 (SOTR) 对 SARS-CoV-2 疫苗接种的抗体反应降低。我们报告说，预先存在的季节性冠状病毒抗体水平升高与 SOTR 中对 SARS-CoV-2 疫苗接种的抗体反应降低有关，这支持抗原印记调节该免疫抑制人群的疫苗反应。
更新日期：2022-08-12
中文翻译：
季节性冠状病毒抗体对实体器官移植受者 SARS-CoV-2 疫苗反应的影响
实体器官移植受者 (SOTR) 对 SARS-CoV-2 疫苗接种的抗体反应降低。我们报告说，预先存在的季节性冠状病毒抗体水平升高与 SOTR 中对 SARS-CoV-2 疫苗接种的抗体反应降低有关，这支持抗原印记调节该免疫抑制人群的疫苗反应。
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