Based on a previously prepared lead compound, a new series of hybrid compounds was prepared and tested against six human tumour cell lines. These new triazole linked tetrahydropyran–oxazole hybrids were prepared evaluating the impact of the LogP for the proposed modifications. The compounds exhibited good antiproliferative results when compared with standards cisplatin and 5-fluorouracil.

中文翻译：

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恶唑-四氢吡喃杂化物的合成及其抗人肿瘤细胞增殖活性研究

基于先前制备的先导化合物，制备了一系列新的杂合化合物，并针对六种人类肿瘤细胞系进行了测试。制备了这些新的三唑连接的四氢吡喃-恶唑杂化物，以评估 LogP 对所提出的修饰的影响。与标准顺铂和 5-氟尿嘧啶相比，这些化合物表现出良好的抗增殖效果。