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Gadolinium based contrast agents (GBCAs): Uniqueness, aquatic toxicity concerns, and prospective remediation
Journal of Contaminant Hydrology ( IF 3.5 ) Pub Date : 2022-08-12 , DOI: 10.1016/j.jconhyd.2022.104057
Idowu Ebenezer Oluwasola 1 , Abdul Latif Ahmad 2 , Noor Fazliani Shoparwe 3 , Suzylawati Ismail 2
Affiliation  

The current toxicity concerns of gadolinium-based contrast agents (GBCAs) have birthed the need to regulate and restrict, in some instances, its clinical administration. However, its tolerable concentration levels in the water sector have not been set. Therefore, the detection and speedy increase of the anthropogenic Gd-GBCAs in the various water bodies, including those serving as the source of drinking water for adults and children, is perturbing. Nevertheless, the strongly canvassed risk-benefit considerations and superior uniqueness of GBCAs compared to the other ferromagnetic metals guarantees its continuous future administration for Magnetic resonance imaging (MRI) investigations regardless of the toxicity concerns. Furthermore, findings have shown that both the advanced and conventional treatment processes of wastewater do not satisfactorily remove GBCAs but rather risk transforming the chelated GBCAs to their free ionic metal (Gd 3+) through inadvertent degradation processes. This unintentional water processing-induced leads to the pathway for unintentional human intake of its free Gd transformative product and exposure to its probable ecotoxicity and several reported inimical effects on human health such as; digestive symptoms, twitching or weakness, cognitive flu, persistent skin diseases, body pains, acute renal and non-renal adverse reactions, chronic skin, and eyes changes. Hence, this work proposed an economical and manageable remediation technique for the potential remediation of Gd-GBCAs in wastewater, while a precautionary limit for Gd in public water and commercial drinks is advocated.



中文翻译:

钆造影剂 (GBCA):独特性、水生毒性问题和前瞻性补救措施

目前钆基造影剂 (GBCA) 的毒性问题催生了在某些情况下对其临床给药进行监管和限制的需要。然而,它在水行业的可容忍浓度水平尚未确定。因此,各种水体(包括作为成人和儿童饮用水源的水体)中人为 Gd-GBCAs 的检测和快速增加令人不安。尽管如此,与其他铁磁金属相比,GBCA 的风险效益考虑和优越的独特性保证了其在未来继续用于磁共振成像 (MRI) 研究,无论毒性问题如何。此外,3+ ) 通过无意的退化过程。这种无意的水处理导致了人类无意摄入其游离 Gd 转化产物的途径,并暴露于其可能的生态毒性和一些报告的对人类健康的不利影响,例如:消化系统症状、抽搐或虚弱、认知流感、持续性皮肤病、身体疼痛、急性肾脏和非肾脏不良反应、慢性皮肤和眼睛变化。因此,这项工作为废水中 Gd-GBCAs 的潜在修复提出了一种经济且可管理的修复技术,同时提倡对公共水和商业饮料中的 Gd 进行预防性限制。

更新日期:2022-08-12
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