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Tuning the surface chemistry of 2D MXenes for optimizing the micellization of bio-targeted carriers
Physica E: Low-dimensional Systems and Nanostructures ( IF 2.9 ) Pub Date : 2022-08-12 , DOI: 10.1016/j.physe.2022.115461
Reza Maleki , Abdolmohammad Alamdari

Using nanocarriers to deliver drugs to cancer cells is an effective way to treat cancer. However, this method faces several challenges, including the instability of nanocarriers, and the appropriate method for the synthesis of nanocarriers. In this regard, in this work, the effect of the two-dimensional MXene in increasing the stability of riboflavin-targeted PLGA-PEG nanocarriers for delivering doxorubicin (Dox) has been investigated using molecular dynamics simulation. In this study, the role of surface chemistry engineering of MXene in optimizing Dox-loaded micelles has been studied. On the other hand, the effect of the microfluidic method on the synthesis of nanocarriers has been investigated. According to the obtained results, the use of MXene has outstandingly increased the stability of Dox-loaded nanocarriers. MXene increases the attraction energy between micelles from −600 Kj/mol to −1700 Kj/mol. But the use of hydrophilic functional groups in the MXene has reduced the stability of nanocarriers. The molecular analysis approves the greater stability of nanocarriers synthesized by the microfluidic method in comparison to non-microfluidic method. Finally, this could lead to the widespread use of microfluidic synthesis as well as MXene in the synthesis of nanocarriers.



中文翻译:

调整 2D MXenes 的表面化学,以优化生物靶向载体的胶束化

利用纳米载体向癌细胞输送药物是治疗癌症的有效方法。然而,这种方法面临着几个挑战,包括纳米载体的不稳定性,以及合成纳米载体的合适方法。在这方面,在这项工作中,已经使用分子动力学模拟研究了二维 MXene在提高核黄素靶向 PLGA-PEG 纳米载体在递送阿霉素 (Dox) 稳定性方面的作用。在本研究中,研究了 MXene 的表面化学工程在优化载有 Dox 的胶束中的作用。另一方面,效果研究了微流控方法合成纳米载体。根据获得的结果,MXene 的使用显着提高了载有 Dox 的纳米载体的稳定性。MXene 将胶束之间的吸引能从 -600 Kj/mol 提高到 -1700 Kj/mol。但是在 MXene 中使用亲水性官能团降低了纳米载体的稳定性。分子分析证实,与非微流体方法相比,通过微流体方法合成的纳米载体具有更高的稳定性。最后,这可能导致微流控合成以及 MXene 在纳米载体合成中的广泛使用。

更新日期:2022-08-12
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