Purpose: HIV-positive people who inject drugs (PWID) in Kazakhstan face many challenges to antiretroviral therapy (ART) adherence. Interventions that leverage social support from an intimate partner, family member, or friend may be effective in improving ART adherence among this population. The purpose of this paper is to describe the implementation process of a dyad-based intervention among HIV-positive PWID and their treatment support partners. Method: Sixty-six HIV-positive PWID and 66 of their treatment support partners will be enrolled in this pilot randomized controlled trial in Almaty, Kazakhstan, and randomized as dyads to receive an adapted version of the SMART Couples intervention or standard of care. Results: Several implementation strategies were used to facilitate intervention delivery, including remote delivery, training of staff, supervision, technical assistance, quality assurance, and collection of assessments through diverse sources. Discussion: This trial responds to a need for dyad-based ART adherence interventions adapted specifically for HIV-positive PWID.

目的：哈萨克斯坦的艾滋病毒阳性注射吸毒者 (PWID) 在坚持抗逆转录病毒治疗 (ART) 方面面临许多挑战。利用亲密伴侣、家庭成员或朋友的社会支持的干预措施可能会有效提高该人群的 ART 依从性。本文的目的是描述艾滋病毒阳性吸毒者及其治疗支持伙伴的二元干预的实施过程。方法： 66 名 HIV 阳性吸毒者及其 66 名治疗支持伙伴将参加在哈萨克斯坦阿拉木图进行的这项试点随机对照试验，并随机分为两组，接受改编版的 SMART Couples 干预或标准护理。结果：采用了多种实施策略来促进干预措施的实施，包括远程实施、工作人员培训、监督、技术援助、质量保证和通过不同来源收集评估。讨论：该试验满足了专门针对 HIV 阳性吸毒者的基于二元的 ART 依从干预措施的需求。