Sympathetic overactivation is one of the main contributors to development and progress of hypertension. Renal denervation (RDN) has been evidenced by series of clinical trials for its efficacy and safety to treat overactivated sympathetic nervous system induced diseases. However, the results were inconsistent and not all patients benefited from RDN. Appropriate patient selection and intraoperative factors to improve the efficacy of RDN need to be solved urgently. Over the decade, research studies on the correlations between indicators and the antihypertensive effects have been conducted and made a fairly well progress. Herein, we comprehensively reviewed the research studies on how to make RDN more predictable or improve the efficacy of RDN and summarized these potential indicators or devices which might be applied in clinical settings.

中文翻译：

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预测肾脏去神经支配疗效的决定因素的现有证据

交感神经过度激活是高血压发展和进展的主要因素之一。肾去神经支配术 (RDN) 已通过一系列临床试验证明其治疗过度激活的交感神经系统诱发疾病的有效性和安全性。然而，结果并不一致，并非所有患者都从 RDN 中受益。适当的患者选择和术中因素以提高RDN的疗效亟待解决。十多年来，对指标与降压效果之间的相关性进行了研究，并取得了较好的进展。在此，我们全面回顾了有关如何使 RDN 更具可预测性或提高 RDN 疗效的研究，并总结了这些可能应用于临床环境的潜在指标或设备。