Purpose. To investigate the changes in thromboelastography (TEG) in patients with dyslipidemia to study its effect on the blood coagulation status. Methods. 131 patients hospitalized in Fujian Provincial Jinshan Hospital from January 2018 to December 2020 were selected, and 64 cases in the hyperlipidemia (HL) group and 67 cases in the non-HL group were set according to whether their blood lipids were abnormal. By measuring the changes of each parameter of TEG in patients, the relevant parameters R value, K value, α angle, and MA value were calculated. And routine blood coagulation (PT, APTT, INR, FIB, and TT) and routine blood (platelet count) tests were performed on all study subjects to analyze the changes of each index of the coagulation function and each parameter of TED in both groups and explore the clinical value of TEG on HL diseases. Results. Compared with the non-HL group, R and K values decreased, and angle and MA values increased in the HL group (). PT, APTT, and INR values decreased, and FIB values increased in the HL group compared with the nonhyperlipidemic group (). The TT levels were similar in the non-HL group and the HL group (). Compared with the non-HL group, PLT values decreased, and PDW and MPV values increased in the HL group (). R value was positively correlated with APTT, r= 0.373, . K value was negatively correlated with PLT, r= −0.399, . α angle and MA values were positively correlated with PLT, r= 0.319/0.475, /. The rest of the indexes did not correlate with each parameter of TEG significant correlation. Conclusion. TEG can predict the hypercoagulability and hypocoagulability of blood by the changes of R value, K value, α angle, and MA to evaluate the effect of hyperlipidemia on the coagulation status, which is important for guiding the adjustment of lipid-lowering, antithrombotic, and anticoagulation programs in patients with atherosclerosis combined with hyperlipidemia or postsurgery combined with hyperlipidemia.

中文翻译：

---

血脂异常患者血栓弹力图变化的意义研究


目的。探讨血脂异常患者血栓弹力图（TEG）的变化，探讨其对凝血状态的影响。方法。选取2018年1月至2020年12月在福建省金山医院住院的131例患者，根据血脂是否异常设置高脂血症（HL）组64例、非HL组67例。通过测量患者TEG各参数的变化，计算相关参数R值、 K值、 α角、MA值。对所有研究对象进行凝血常规（PT、APTT、INR、FIB、TT）和血常规（血小板计数）检测，分析两组患者凝血功能各指标及TED各参数的变化情况。探讨TEG对HL疾病的临床价值。结果。与非HL组相比，HL组的R和K值降低，角度和MA值增加（ ）。与非高脂血症组相比，HL组的PT、APTT和INR值降低，FIB值升高（ ）。非 HL 组和 HL 组的 TT 水平相似（ ）。与非HL组相比，HL组PLT值降低，PDW和MPV值升高（ ）。 R值与APTT呈正相关， r =0.373， 。 K值与PLT呈负相关， r =-0.399， 。 α角和MA值与PLT呈正相关， r =0.319/0。第475章 。其余指标与TEG各参数均不存在显着相关性。结论。 TEG可通过R值、 K值、 α角、MA的变化来预测血液的高凝和低凝状态，评价高脂血症对凝血状态的影响，对于指导降脂、抗栓、抗凝等药物的调整具有重要意义。动脉粥样硬化合并高脂血症或术后合并高脂血症患者的抗凝方案。