The commonly indolent chronic lymphocytic leukemia may evolve into Richter transformation (RT), a very aggressive large B cell lymphoma. We identified early seeding of RT cells decades before its final expansion, mapped the underlying (epi)genomic alterations driving this process, and validated in vitro potential actionable therapeutic pathways.

中文翻译：

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Richter 转化细胞的克隆进化揭示了治疗漏洞

通常惰性的慢性淋巴细胞白血病可能会演变成里氏转化 (RT)，这是一种非常具有侵袭性的大 B 细胞淋巴瘤。我们在 RT 细胞最终扩增前几十年确定了早期播种，绘制了驱动这一过程的潜在（表观）基因组改变，并在体外验证了潜在的可行治疗途径。