Purpose To assess the incidence of persistent subfoveal fluid (PSFF) in pneumatic retinopexy (PnR) versus pars plana vitrectomy (PPV) following rhegmatogenous retinal detachment (RRD) repair and to determine its association with functional outcomes. Methods Posthoc analysis of the PIVOT randomised trial. Eyes with gradable en face and cross-sectional spectral-domain optical coherence tomography (SD-OCT) scans at 1–2 months postoperatively were included. Primary outcome was the proportion of patients with PSFF following PnR versus PPV at 1–2 months postoperatively. Secondary outcomes included association of PSFF with Early Treatment Diabetic Retinopathy Study (ETDRS) letter score at 3, 6 and 12 months and metamorphopsia score (MCHARTs) at 12 months. Results Of 176 participants enrolled in PIVOT, 158 (89.8%) had gradable SD-OCT scans. Intergrader agreement was 0.870 (Cohen’s kappa). The incidence of PSFF was 16% (13/81) following PnR and 10.4% (8/77) following PPV (p=0.298; OR=1.65, 95% CI 0.64 to 4.23). Median ETDRS score at 3 months postoperatively between eyes with and without PSFF was 71 (IQR=58–78) and 78 (IQR=70–84), respectively (difference=7 letters, p=0.037), with no significant difference at subsequent 6-month and 12-month visits. Median metamorphopsia scores in patients with versus without PSFF were: horizontal: 0.1 (IQR=0–0.3) vs 0 (IQR=0–0.2) (difference=0.1, p=0.228) and vertical: 0.25 (IQR=0–0.4) vs 0 (IQR=0–0.2) (difference=0.25, p=0.148), respectively. Conclusions There was no significant difference in the incidence of PSFF in eyes undergoing PnR versus PPV for RRD. The presence of PSFF at 1–2 months postoperatively was associated with worse ETDRS letter score at 3 months, but there was no difference at 1 year. Trial registration number [NCT01639209][1]. All data relevant to the study are included in the article or uploaded as supplementary information. [1]: /lookup/external-ref?link_type=CLINTRIALGOV&access_num=NCT01639209&atom=%2Fbjophthalmol%2F107%2F11%2F1693.atom

中文翻译：

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气动视网膜固定术与平坦部玻璃体切除术治疗孔源性视网膜脱离中持续存在的中心凹下积液：PIVOT 随机试验的事后分析

目的 评估孔源性视网膜脱离 (RRD) 修复术后气动视网膜固定术 (PnR) 与平坦部玻璃体切除术 (PPV) 中持续存在中心凹下积液 (PSFF) 的发生率，并确定其与功能结果的相关性。方法 PIVOT 随机试验的事后分析。包括术后 1-2 个月进行可分级正面扫描和横截面谱域光学相干断层扫描 (SD-OCT) 扫描的眼睛。主要结局是术后 1-2 个月 PnR 与 PPV 后出现 PSFF 的患者比例。次要结局包括 PSFF 与 3、6 和 12 个月时的早期治疗糖尿病视网膜病变研究 (ETDRS) 字母评分以及 12 个月时的视物变形评分 (MCHART) 的关联。结果 在参加 PIVOT 的 176 名参与者中，158 名 (89.8%) 进行了可分级的 SD-OCT 扫描。分级器一致性为 0.870（Cohen 的 kappa）。PnR 后 PSFF 的发生率为 16% (13/81)，PPV 后 PSFF 的发生率为 10.4% (8/77)（p=0.298；OR=1.65，95% CI 0.64 至 4.23）。术后 3 个月，有 PSFF 和无 PSFF 的眼睛之间的中位 ETDRS 评分分别为 71 (IQR=58-78) 和 78 (IQR=70-84)（差异=7 个字母，p=0.037），随后的随访中无显着差异。 6个月和12个月的访问。患有 PSFF 的患者与不患有 PSFF 的患者的中位变形评分为：水平：0.1 (IQR=0–0.3) vs 0 (IQR=0–0.2)（差异=0.1，p=0.228）和垂直：0.25 (IQR=0–0.4)分别与 0 (IQR=0–0.2)（差异=0.25，p=0.148）。结论 在接受 PnR 与 PPV 治疗 RRD 的眼睛中，PSFF 的发生率没有显着差异。术后 1-2 个月出现 PSFF 与 3 个月时较差的 ETDRS 字母评分相关，但 1 年时没有差异。试用注册号[NCT01639209][1]。与研究相关的所有数据都包含在文章中或作为补充信息上传。[1]: /lookup/external-ref?link_type=CLINTRIALGOV&access_num=NCT01639209&atom=%2Fbjophamol%2F107%2F11%2F1693.atom