Selective C(sp2)–H bond functionalization of olefins via visible-light-induced photoredox-quinuclidine dual catalysis,Chemical Communications

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Selective C(sp2)–H bond functionalization of olefins via visible-light-induced photoredox-quinuclidine dual catalysis
Chemical Communications ( IF 4.3 ) Pub Date : 2022-08-12 , DOI: 10.1039/d2cc03694k
Xin-Tao Gu ₁ , Long-Hai Li ₁ , Yin Wei ₁ , Min Shi ₁

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The site selective C(sp²)–H bond functionalization of olefins has been achieved through a visible-light-induced photoredox-quinuclidine dual catalysis upon merging the quinuclidinium radical cation addition to alkene strategy and the distal heteroaryl ipso-migration strategy. This synthetic protocol features a simple operation with readily available starting materials in good step-economy to access alkenylheteroaromatic products in moderate to good yields under mild conditions. A plausible cascade catalytic reaction mechanism is also proposed.

中文翻译：

通过可见光诱导的光氧化还原-奎宁环双催化对烯烃的选择性 C(sp2)-H 键官能化

烯烃的位点选择性 C(sp ² )-H 键功能化是通过将quinuclidinium自由基阳离子加成与烯烃策略和远端杂芳基同位迁移策略相结合，通过可见光诱导的光氧化还原 - 奎宁环双催化实现的。该合成协议的特点是操作简单，起始材料易于获得，具有良好的分步经济性，可在温和条件下以中等至良好的产率获得烯基杂芳烃产品。还提出了一种似是而非的级联催化反应机理。

更新日期：2022-08-12

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