Impact of muscle mass on survival of patients with hepatocellular carcinoma after liver transplantation beyond the Milan criteria,Journal of Cachexia, Sarcopenia and Muscle

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Impact of muscle mass on survival of patients with hepatocellular carcinoma after liver transplantation beyond the Milan criteria
Journal of Cachexia, Sarcopenia and Muscle ( IF 9.4 ) Pub Date : 2022-08-10 , DOI: 10.1002/jcsm.13053
Berend R Beumer ₁ , Jeroen L A van Vugt ₁ , Gonzalo Sapisochin ₂ , Peter Yoon _{2,

3} , Marco Bongini ₄ , Di Lu ₅ , Xiao Xu ₅ , Paolo De Simone ₆ , Lorenzo Pintore ₆ , Nicolas Golse ₇ , Malgorzata Nowosad ₈ , William Bennet ₉ , Emmanouil Tsochatzis ₁₀ , Evangelia Koutli ₁₀ , Fariba Abbassi ₁₁ , Marco P A W Claasen _{1,

2} , Manuela Merli ₁₂ , Joanne O'Rourke ₁₃ , Martina Gambato ₁₄ , Alberto Benito ₁₅ , Avik Majumdar ₁₆ , Ek Khoon Tan ₁₇ , Maryam Ebadi ₁₈ , Aldo J Montano-Loza ₁₈ , Marina Berenguer ₁₉ , Herold J Metselaar ₂₀ , Wojciech G Polak ₁ , Vincenzo Mazzaferro ₄ , Jan N M IJzermans ₁ ,

Affiliation

Erasmus MC Transplant Institute, Department of Surgery, Division of HPB & Transplant Surgery, University Medical Centre Rotterdam, Rotterdam, The Netherlands.
Multi Organ Transplant Program, University Health Network, University of Toronto, Toronto, Canada.
Department of Surgery, Westmead Hospital, Sydney, Australia.
Gastrointestinal Surgery and Liver Transplantation, National Cancer Institute of Milan, Department of Oncology, University of Milan, Milan, Italy.
Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Hepatobiliary Surgery and Liver Transplantation, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.
Centre Hépato-Biliaire, Hôpital Paul Brousse, Université Paris-Sud, Villejuif, France.
Department of General Transplant and Liver Surgery, Medical University of Warsaw, Warsaw, Poland.
Transplant Institute, Sahlgrenska University Hospital, Sahlgrenska Academy, Gothenburg, Sweden.
Royal Free Sheila Sherlock Liver Centre, Royal Free Hospital and UCL Institute of Liver and Digestive Health, London, UK.
Division of Digestive Surgery, University Hospitals of Geneva, Genève, Switzerland.
Section of Gastroenterology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
The Liver Unit, Queen Elizabeth Hospital Birmingham, Birmingham, UK.
Section of Gastroenterology, Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy.
Section of Radiology, Clinica Universidad de Navarra, Pamplona, Spain.
AW Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, Sydney, Australia.
Department of Hepatopancreatobiliary and Transplant Surgery, Singapore General Hospital, Singapore.
Division of Gastroenterology and Liver Unit, Zeidler Ledcor Centre, University of Alberta, Edmonton, Canada.
Hepatology & Liver Transplantation Unit and Ciberehd and ISS La Fe, Hospital Universitario y Politécnico La Fe, University of Valencia, Valencia, Spain.
Erasmus MC Transplant Institute, Department of Gastroenterology and Hepatology, University Medical Centre Rotterdam, Rotterdam, The Netherlands.

Access to the liver transplant waitlist for patients with hepatocellular carcinoma (HCC) depends on tumour presentation, biology, and response to treatments. The Milan Criteria (MC) represent the benchmark for expanded criteria that incorporate additional prognostic factors. The purpose of this study was to determine the added value of skeletal muscle index (SMI) in HCC patients beyond the MC.

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