Pressure-insensitive azeotropes are often encountered in chemical production. Entrainer-assisted pressure-swing distillation (EAPSD) is a special pressure-swing distillation showing promising performance in separating pressure-insensitive azeotropes. However, few studies have been reported on this method. In this work, the comparison between the EAPSD with tetrahydrofuran as pressure-sensitive entrainer and extractive distillation (ED) with dimethyl sulfoxide as solvent in separating water/isopropanol azeotrope is performed to explore the performance of EAPSD. Different EAPSD sequences, low-high sequence (LHS) and high-low sequence (HLS), are designed with different product sequences. A strategy considering the possibility of both partial and full heat integration is used to reduce capital cost and energy consumption. Multi-objective genetic algorithm is applied to achieve the optimal performance. The results show that the heat-integrated HLS sequence has lower total annual cost (TAC) by 7.04% and lower CO₂ emission (CDE) by 4.27% than LHS, while ED process has lower TAC and CDE by 51.80% and 36.96% than the optimal EAPSD process.

在化工生产中经常遇到压力不敏感的共沸物。共沸剂辅助变压蒸馏（EAPSD）是一种特殊的变压蒸馏，在分离压力不敏感的共沸物方面表现出良好的性能。然而，很少有关于这种方法的研究报道。在这项工作中，比较了以四氢呋喃为压敏共沸剂的 EAPSD 与以二甲亚砜为溶剂的萃取蒸馏 (ED) 在分离水/异丙醇共沸混合物中的性能，以探索 EAPSD 的性能。不同的EAPSD序列，低-高序列（LHS）和高-低序列（HLS），设计有不同的产品序列。考虑到部分和全部热集成的可能性的策略用于降低资本成本和能源消耗。采用多目标遗传算法实现最优性能。结果表明，热集成 HLS 序列的总年成本 (TAC) 降低了 7.04%，CO₂排放（CDE）比LHS低4.27%，而ED工艺的TAC和CDE比最优EAPSD工艺低51.80%和36.96%。