Mitochondrial energetics and respiration have emerged as important factors in how cancer cells respond to or evade apoptotic signals. The study of the functional connection between these two processes may provide insight into following questions old and new: how might we target respiration or downstream signaling pathways to amplify apoptotic stress in the context of cancer therapy? Why are respiration and apoptotic regulation housed in the same organelle? Here, we briefly review mitochondrial respiration and apoptosis and then focus on how the intersection of these two processes is regulated by cytoplasmic signaling pathways such as the integrated stress response.

线粒体能量和呼吸已成为癌细胞如何响应或逃避凋亡信号的重要因素。对这两个过程之间功能联系的研究可能有助于深入了解以下新旧问题：在癌症治疗中，我们如何靶向呼吸或下游信号通路来放大细胞凋亡应激？为什么呼吸和细胞凋亡调节位于同一个细胞器中？在这里，我们简要回顾线粒体呼吸和细胞凋亡，然后重点讨论这两个过程的交叉如何受到细胞质信号通路（例如整合应激反应）的调节。