Nitrofurazone (NFZ) is carcinogenic and mutagenic to human in long-term ingestion, and it is prohibited to be added in food. In this work, a novel triphenylbenzene (TPB) functionalized fluorescent hybrid porous polymers (POSS@TPB) was constructed by using polyhedral oligomeric silsesquioxane (POSS) as the rigid group and TPB as the core unit of high fluorescence. The morphology and physicochemical properties of POSS@TPB were characterized in detail. Moreover, the synergistic effect of inner filter effect and photoinduced electron transfer is verified by experimental and simulation results. After condition optimization, a NFZ analysis method based on POSS@TPB probe was established with a linear range of 0.4–16.5 mg/L and a detection limit of 0.13 mg/L. In addition, the fluorescent probe has good stability, anti-interference and considerable reusability. At the same time, the selective analysis of trace NFZ in aquatic product and cosmetics was carried out with satisfied recoveries of 87%–110.6% and relative standard deviation less than 4.1%. And the results were verified by high-performance liquid chromatography method. Overall, this fluorescence sensor has excellent performance in NFZ analysis, which provides a broad application prospect for the repeatable and selective residue NFZ analysis in aquatic product and cosmetics.

呋喃西林（NFZ）对人体具有致癌性和致突变性，长期摄入，禁止在食品中添加。在这项工作中，以多面体低聚倍半硅氧烷（POSS）为刚性基团，TPB为高荧光核心单元，构建了一种新型的三苯基苯（TPB）功能化荧光杂化多孔聚合物（POSS@TPB）。详细表征了POSS@TPB的形貌和理化性质。此外，通过实验和模拟结果验证了内滤效应和光致电子转移的协同效应。经过条件优化，建立了基于POSS@TPB探针的NFZ分析方法，线性范围为0.4~16.5 mg/L，检出限为0.13 mg/L。此外，荧光探针具有良好的稳定性，抗干扰性和可重用性。同时对水产品和化妆品中痕量NFZ进行选择性分析，回收率达87%~110.6%，相对标准偏差小于4.1%。并用高效液相色谱法对结果进行了验证。总体而言，该荧光传感器在NFZ分析中具有优异的性能，为水产品和化妆品中可重复、选择性的残留NFZ分析提供了广阔的应用前景。