当前位置: X-MOL 学术Nat. Rev. Nephrol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
A polygenic score predicts CKD across ancestries
Nature Reviews Nephrology ( IF 28.6 ) Pub Date : 2022-08-11 , DOI: 10.1038/s41581-022-00622-8
Inga Steinbrenner 1 , Anna Köttgen 1
Affiliation  

Chronic kidney disease (CKD) is often well advanced before it is detected. Although polygenic scores may enable the early stratification of patients at risk of CKD, the transferability of polygenic scores for the prediction of CKD to populations of non-European ancestry was limited. A new cross-ancestry polygenic score for CKD overcomes these issues, demonstrating good performance across ancestries.

中文翻译:

多基因评分可预测跨血统的 CKD

慢性肾脏病 (CKD) 在被发现之前通常已经很晚了。尽管多基因评分可以对有 CKD 风险的患者进行早期分层,但用于预测 CKD 到非欧洲血统人群的多基因评分的可转移性是有限的。一种新的 CKD 跨血统多基因评分克服了这些问题,证明了跨血统的良好表现。
更新日期:2022-08-11
down
wechat
bug