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Fatal Fungicide-Associated Triazole-Resistant Aspergillus fumigatus Infection, Pennsylvania, USA
Emerging Infectious Diseases ( IF 11.8 ) Pub Date : 2022-08-10 , DOI: 10.3201/eid2809.220517
Kennedy Bradley , Audrey Le-Mahajan , Beth Morris , Tiina Peritz , Tom Chiller , Kaitlin Forsberg , Natalie S. Nunnally , Shawn R. Lockhart , Jeremy A.W. Gold , Jane M. Gould

We report a fatal infection in a 65-year-old immunocompromised male patient caused by pan-triazole–resistant Aspergillus fumigatus containing a TR34/L98H genetic mutation linked to agricultural fungicide use. Clinical and environmental surveillance of triazole-resistant A. fumigatus is needed in the United States to prevent spread and guide healthcare and agricultural practices.



中文翻译:

致命杀真菌剂相关的三唑抗性烟曲霉感染,美国宾夕法尼亚州

我们报告了一名 65 岁免疫功能低下男性患者的致命感染,该感染是由耐泛三唑的烟曲霉引起的,该烟曲霉含有与农业杀菌剂使用相关的 TR 34 /L98H 基因突变。美国需要对耐三唑的烟曲霉进行临床和环境监测,以防止传播并指导医疗保健和农业实践。

更新日期:2022-08-11
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