The impact of COVID-19 on population health is recognised as being substantial, yet few studies have attempted to quantify to what extent infection causes mild or moderate symptoms only, requires hospital and/or ICU admission, results in prolonged and chronic illness, or leads to premature death. We aimed to quantify the total disease burden of acute COVID-19 in the Netherlands in 2020 using the disability-adjusted life-years (DALY) measure, and to investigate how burden varies between age-groups and occupations. Using standard methods and diverse data sources (mandatory notifications, population-level seroprevalence, hospital and ICU admissions, registered COVID-19 deaths, and the literature), we estimated years of life lost (YLL), years lived with disability, DALY and DALY per 100,000 population due to COVID-19, excluding post-acute sequelae, stratified by 5-year age-group and occupation category. The total disease burden due to acute COVID-19 was 286,100 (95% CI: 281,700–290,500) DALY, and the per-capita burden was 1640 (95% CI: 1620–1670) DALY/100,000, of which 99.4% consisted of YLL. The per-capita burden increased steeply with age, starting from 60 to 64 years, with relatively little burden estimated for persons under 50 years old. SARS-CoV-2 infection and associated premature mortality was responsible for a considerable direct health burden in the Netherlands, despite extensive public health measures. DALY were much higher than for other high-burden infectious diseases, but lower than estimated for coronary heart disease. These findings are valuable for informing public health decision-makers regarding the expected COVID-19 health burden among population subgroups, and the possible gains from targeted preventative interventions.

人们认为 COVID-19 对人口健康的影响是巨大的，但很少有研究试图量化感染在多大程度上仅导致轻度或中度症状、需要住院和/或 ICU 住院、导致长期和慢性疾病或导致以致过早死亡。我们的目标是使用伤残调整生命年 (DALY) 指标来量化 2020 年荷兰急性 COVID-19 的总疾病负担，并调查不同年龄组和职业之间的负担差异。使用标准方法和不同的数据源（强制通知、人群血清流行率、医院和 ICU 入院情况、登记的 COVID-19 死亡人数和文献），我们估计了生命损失年数 (YLL)、残疾寿命年、DALY 和 DALY每 10 万人因 COVID-19 造成的死亡人数（不包括急性后遗症），按 5 岁年龄组和职业类别分层。急性COVID-19引起的总疾病负担为286,100 (95% CI: 281,700–290,500) DALY，人均负担为1640 (95% CI: 1620–1670) DALY/100,000，其中99.4%包括YLL。人均负担随着年龄的增长而急剧增加，从60岁到64岁，估计50岁以下的人的负担相对较小。尽管采取了广泛的公共卫生措施，但 SARS-CoV-2 感染和相关的过早死亡给荷兰带来了相当大的直接健康负担。 DALY远高于其他高负担传染病，但低于冠心病的估计值。这些发现对于让公共卫生决策者了解人口亚群中预期的 COVID-19 健康负担以及有针对性的预防干预措施可能带来的收益非常有价值。