Cell Biology and Toxicology ( IF 5.3 ) Pub Date : 2022-08-11 , DOI: 10.1007/s10565-022-09716-2 Yang Bai 1 , Jinjing Wu 1 , Zhenyu Yang 2 , Xu'an Wang 1 , Dongni Zhang 1 , Jun Ma 1
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The current effective method for the treatment of myocardial infarction is timely restoration of the blood supply to the ischemic area of the heart. Although reperfusion is essential for reestablishing oxygen and nutrient supplies, it often leads to additional myocardial damage, creating an important clinical dilemma. Reports from long-term studies have confirmed that mitochondrial damage is the critical mechanism in cardiac ischemia/reperfusion (I/R) injury. Mitochondria are dynamic and possess a quality control system that targets mitochondrial quantity and quality by modifying mitochondrial fusion, fission, mitophagy, and biogenesis and protein homeostasis to maintain a healthy mitochondrial network. The system of mitochondrial quality control involves complex molecular machinery that is highly interconnected and associated with pathological changes such as oxidative stress, calcium overload, and endoplasmic reticulum (ER) stress. Because of the critical role of the mitochondrial quality control systems, many reports have suggested that defects in this system are among the molecular mechanisms underlying myocardial reperfusion injury. In this review, we briefly summarize the important role of the mitochondrial quality control in cardiomyocyte function and focus on the current understanding of the regulatory mechanisms and molecular pathways involved in mitochondrial quality control in cardiac I/R damage.
Graphical abstract
中文翻译：
心肌缺血/再灌注损伤中的线粒体质量控制：机制和意义的新见解
目前治疗心肌梗死的有效方法是及时恢复心脏缺血区的血液供应。尽管再灌注对于重建氧气和营养供应至关重要，但它通常会导致额外的心肌损伤，从而造成重要的临床困境。长期研究报告证实，线粒体损伤是心肌缺血/再灌注（I/R）损伤的关键机制。线粒体是动态的，拥有一个质量控制系统，通过修改线粒体融合、裂变、线粒体自噬、生物发生和蛋白质稳态来维持线粒体网络的健康，从而针对线粒体的数量和质量。线粒体质量控制系统涉及复杂的分子机制，这些分子机制高度相互关联，并与氧化应激、钙过载和内质网 (ER) 应激等病理变化相关。由于线粒体质量控制系统的关键作用，许多报告表明该系统的缺陷是心肌再灌注损伤的分子机制之一。在这篇综述中，我们简要总结了线粒体质量控制在心肌细胞功能中的重要作用，并重点介绍了目前对线粒体质量控制在心脏 I/R 损伤中所涉及的调控机制和分子通路的理解。由于线粒体质量控制系统的关键作用，许多报告表明该系统的缺陷是心肌再灌注损伤的分子机制之一。在这篇综述中，我们简要总结了线粒体质量控制在心肌细胞功能中的重要作用，并重点介绍了目前对线粒体质量控制在心脏 I/R 损伤中所涉及的调控机制和分子通路的理解。由于线粒体质量控制系统的关键作用，许多报告表明该系统的缺陷是心肌再灌注损伤的分子机制之一。在这篇综述中，我们简要总结了线粒体质量控制在心肌细胞功能中的重要作用，并重点介绍了目前对线粒体质量控制在心脏 I/R 损伤中所涉及的调控机制和分子通路的理解。
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