Natural cells (NCs) can automatically and continuously respond to fluctuant external information and distinguish meaningful stimuli from weak noise depending on their powerful genetic and protein networks. We herein report a network topology–directed design of dynamic molecular processing system (DMPS) as a molecular central processing unit that powers an artificial cell (AC) able to process fluctuant information in its immediate environment similar to NCs. By constructing a mixed cell community, ACs and NCs have synchronous response to fluctuant extracellular stimuli under physiological condition and in a blood vessel–mimic circulation system. We also show that fluctuant bioinformation released by NCs can be received and processed by ACs. The molecular design of DMPS-powered AC is expected to allow a profound understanding of biological systems, advance the construction of intelligent molecular systems, and promote more elegant bioengineering applications.

中文翻译：

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用于类细胞动态信息处理的分子 CPU 的网络拓扑定向设计

自然细胞 (NCs) 可以自动和持续地响应波动的外部信息，并根据其强大的遗传和蛋白质网络将有意义的刺激与微弱的噪音区分开来。我们在此报告了动态分子处理系统 (DMPS) 的网络拓扑导向设计，作为分子中央处理单元，为人工细胞 (AC) 提供动力，能够在其直接环境中处理类似于 NC 的波动信息。通过构建混合细胞群落，AC 和 NC 在生理条件下和模拟血管循环系统中对波动的细胞外刺激具有同步响应。我们还表明，AC 可以接收和处理 NC 发布的波动生物信息。DMPS 供电交流电的分子设计有望让人们对生物系统有深刻的理解，