Immune-checkpoint blockade therapy has been successfully applied to many cancers, particularly tumors that harbor a high mutational burden and consequently express a high abundance of neoantigens. However, novel approaches are needed to improve the efficacy of immunotherapy for treating tumors that lack a high load of classic genetically derived neoantigens. Recent discoveries of broad classes of nongenetically encoded and inducible neoepitopes open up new avenues for therapeutic development to enhance sensitivity to immunotherapies. In this review, we discuss recent work on neoantigen discovery, with an emphasis on novel classes of noncanonical neoepitopes.

中文翻译：

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通过扩大新表位景观增强抗肿瘤免疫力


免疫检查点阻断疗法已成功应用于许多癌症，特别是具有高突变负荷并因此表达高丰度新抗原的肿瘤。然而，需要新的方法来提高免疫疗法治疗缺乏高负载经典遗传衍生新抗原的肿瘤的疗效。最近发现的广泛类别的非基因编码和可诱导的新表位为增强免疫疗法敏感性的治疗开发开辟了新途径。在这篇综述中，我们讨论了新抗原发现的最新工作，重点是新类别的非经典新表位。