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Pyruvate Metabolism Enables Antitumor Succinate Signaling in CD8+ T Cells.
Cancer Discovery ( IF 29.7 ) Pub Date : 2022-09-02 , DOI: 10.1158/2159-8290.cd-rw2022-133


Tumor-derived lactate disrupts pyruvate metabolism and cytotoxic function of antitumor CD8+ T cells.

中文翻译:

丙酮酸代谢使 CD8+ T 细胞中的抗肿瘤琥珀酸信号转导成为可能。

肿瘤来源的乳酸破坏了抗肿瘤 CD8+ T 细胞的丙酮酸代谢和细胞毒功能。
更新日期:2022-07-29
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