Sjogren's syndrome (SS) is characterized as an autoimmune disorder targeting secretory glands, including the lacrimal and salivary glands, causing dry eye and dry mouth predominantly in women over the age of 40. In this review, we summarize recent advancements in SS diagnostics, treatments, and our understanding of correlations between oral and ocular manifestations of SS. Google Scholar and PubMed databases were utilized to search peer-reviewed papers since 2016 on SS diagnosis, treatment, and correlations between oral and ocular manifestations. For diagnostics, we discuss the updated SS classification criteria by the American College of Rheumatology/European League Against Rheumatism (ACR/EULAR), new biomarkers, and compare studies of current diagnostic methods with alternative technologies. For treatments, we discuss topical, systemic, and surgical treatment developments in the management of oral and ocular symptoms of SS as there is still no cure for the disorder. Finally, we report studies that directly suggest correlations between the ocular surface disease and oral disease in SS, as well as shared abnormalities in the microbiome and cytokine expression that may be correlated. We conclude by stating limitations to our review as well as paths moving forward. Elucidating correlations between oral and ocular manifestations may be the key to furthering our understanding of SS pathogenesis as well as defining new standards for diagnosis and treatment.

干燥综合征(SS) 的特征是针对分泌腺（包括泪腺和唾液腺）的自身免疫性疾病, 主要导致 40 岁以上的女性眼干和口干。在这篇综述中，我们总结了 SS 诊断、治疗的最新进展，以及我们对 SS 口腔和眼部表现之间相关性的理解。自 2016 年以来，谷歌学术和 PubMed 数据库被用于搜索关于 SS 诊断、治疗以及口腔和眼部表现之间相关性的同行评审论文。对于诊断，我们讨论了美国风湿病学会/欧洲抗风湿病联盟 (ACR/EULAR) 更新的 SS 分类标准、新的生物标志物，并将当前诊断方法的研究与替代技术进行了比较。对于治疗，我们讨论了 SS 口腔和眼部症状管理方面的局部、全身和手术治疗进展，因为该疾病仍无法治愈。最后，SS 中的眼表疾病和口腔疾病，以及可能相关的微生物组和细胞因子表达的共同异常。最后，我们说明了我们审查的局限性以及前进的道路。阐明口腔和眼部表现之间的相关性可能是加深我们对 SS 发病机制的理解以及定义诊断和治疗新标准的关键。