We read the manuscript by van Meel et al. [1] with interest as they have investigated the relationship between early-life infection and both later asthma and lower lung function in school-aged children of the general population, to address an internationally recognised research gap. Using primary data from 150 090 children from 38 participating pregnancy and birth cohorts across Europe, mainly from the EU Child Cohort Network [2], the authors grouped several different types of upper (URTIs) and lower respiratory tract infections (LRTIs) separately as binary exposures and then meta-analysed the individual participant data. Specifically in reference to school-aged asthma, table 3 summarised the positive associations for early-life respiratory infection, which were highest for LRTIs within the stratum of participants without early-life wheezing (i.e. statistically significant 2.1- to 2.7-fold increases in the odds), followed by LRTIs with early-life wheezing (i.e. significant 1.4- to 1.9-fold increases in the odds), URTIs without early-life wheezing (i.e. significant 1.1- to 1.2-fold increases in the odds), and URTIs with early-life wheezing (i.e. generally non-significant 1.0- to 1.2-fold increases in the odds).

我们阅读手稿货车米鳗鱼 等。[1] 感兴趣的是，他们调查了普通人群学龄儿童早期感染与后期哮喘和肺功能下降之间的关系，以解决国际公认的研究空白。使用来自欧洲 38 个参与妊娠和出生队列的 150 090 名儿童的主要数据，主要来自欧盟儿童队列网络 [2]，作者将几种不同类型的上呼吸道感染 (URTI) 和下呼吸道感染 (LRTI) 分别分组为二元暴露，然后对个体参与者数据进行荟萃分析。特别针对学龄期哮喘，表 3 总结了生命早期呼吸道感染的正相关性，在没有生命早期喘息的参与者阶层中，LRTIs 的相关性最高（即概率显着增加 2.1 至 2.7 倍），其次是伴有早年喘息的 LRTI（即概率显着增加 1.4 至 1.9 倍），无早年喘息的 URTI（即显着增加 1.1 至1.9 倍）几率增加 1.2 倍），以及 URTI 伴有早年喘息（即几率增加 1.0 至 1.2 倍，但通常不显着）。