We have read the correspondence of J.L. Perret and co-workers regarding our meta-analyses on early-life respiratory tract infections and the risk of school-age lower lung function and asthma [1] with great interest, and thank them for their critical appraisal. In their correspondence, two main comments are raised. First, whether children with upper respiratory tract infections without (concomitant) lower respiratory tract infections in early life would have similar odds of school-age asthma as presented, and second, whether differential misclassification of school-age asthma might have affected our findings of the association of upper respiratory tract infections in early life with school-age asthma.

我们非常感兴趣地阅读了 JL Perret 及其同事关于我们对生命早期呼吸道感染和学龄期肺功能低下和哮喘风险 [1] 的荟萃分析的信件，并感谢他们的批评性评价. 在他们的信件中，提出了两个主要意见。首先，在生命早期没有（伴随）下呼吸道感染的上呼吸道感染儿童患学龄期哮喘的几率是否与所提出的相似，其次，对学龄期哮喘的差异性错误分类是否可能影响我们的发现生命早期上呼吸道感染与学龄期哮喘的关联。