To develop an anticoagulant coating for polyethylene terephthalate (PET) fabric-covered stents, we prepared a series of ultraviolet (UV)-curable coatings with different film-forming compositions and enoxaparin sodium ratios. We then investigated their mechanical properties and hydrophilicity by adhesion, pencil hardness, abrasion resistance tests, and water contact angle measurements. In addition, their biocompatibility and cytotoxicity were evaluated by their protein adsorption, platelet adhesion, and plasma recalcification times, and by CCK-8 assays. Finally, an anticoagulant coating with excellent mechanical properties, biocompatibility, and low cytotoxicity was obtained, offering a feasible scheme for covered stents in clinical practice.

为了开发用于聚对苯二甲酸乙二醇酯 (PET) 织物覆盖支架的抗凝涂层，我们制备了一系列具有不同成膜成分和依诺肝素钠比例的紫外线 (UV) 固化涂层。然后，我们通过附着力、铅笔硬度、耐磨性测试和水接触角测量来研究它们的机械性能和亲水性。此外，它们的生物相容性和细胞毒性通过它们的蛋白质吸附、血小板粘附和血浆再钙化时间以及 CCK-8 测定来评估。最终获得了具有优异机械性能、生物相容性和低细胞毒性的抗凝涂层，为临床上覆膜支架提供了可行的方案。