Advanced solid phase extraction (SPE) fibrous sorbents including polyethylene, polypropylene poly (hydroxybutyrate), and polyamide 6 nanofibers, polycaprolactone microfibers/nanofibers, polycaprolactone microfibers/polyvinylidene difluoride nanofibers, and poly (hydroxybutyrate) microfibers/polypropylene microfibers composites, as well as commercial molecularly imprinted polymers and restricted access media sorbent were compared in terms of bisphenols extraction from milk and their clean-up efficiency. Three on-line SPE-HPLC methods were completely validated for the extraction and detection of bisphenols A, AF, C, A diglycidyl ether, and F diglycidyl ether in bovine milk. Polycaprolactone composite nanofibers compared favorably to restricted access media, enabled excellent clean-up of bisphenols from the proteinaceous matrix, and yielded recoveries 98.0–124.5% and 93.0–115.0%, respectively, with RSD less than 10%. Total analysis time including on-line SPE step lasted only 12 min, which represents a significant reduction in time compared with previously reported as well as official European Union and AOAC methods defined for the determination of bisphenols in various matrices.

高级固相萃取 (SPE) 纤维吸附剂，包括聚乙烯、聚丙烯聚（羟基丁酸酯）和聚酰胺 6 纳米纤维、聚己内酯微纤维/纳米纤维、聚己内酯微纤维/聚偏二氟乙烯纳米纤维和聚（羟基丁酸酯）微纤维/聚丙烯微纤维复合材料，以及商用在从牛奶中提取双酚及其净化效率方面比较了分子印迹聚合物和限制进入介质吸附剂。三种在线 SPE-HPLC 方法对提取和检测牛奶中的双酚 A、AF、C、A 二缩水甘油醚和 F 二缩水甘油醚进行了全面验证。聚己内酯复合纳米纤维与限制进入介质相比具有优势，能够从蛋白质基质中出色地清除双酚，回收率分别为 98.0–124.5% 和 93.0–115.0%，RSD 小于 10%。包括在线 SPE 步骤在内的总分析时间仅持续 12 分钟，与之前报告的以及为测定各种基质中的双酚类物质而定义的官方欧盟和 AOAC 方法相比，时间显着减少。