Case-only design identifies interactions of genetic risk variants at SIGLEC5 and PLG with the lncRNA CTD-2353F22.1 implying the importance of periodontal wound healing for disease aetiology,Journal of Clinical Periodontology

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Case-only design identifies interactions of genetic risk variants at SIGLEC5 and PLG with the lncRNA CTD-2353F22.1 implying the importance of periodontal wound healing for disease aetiology
Journal of Clinical Periodontology ( IF 5.8 ) Pub Date : 2022-08-10 , DOI: 10.1111/jcpe.13712
Ricarda Müller ₁ , Sandra Freitag-Wolf ₂ , January Weiner ₃ , Avneesh Chopra ₁ , Tugba Top ₁ , Henrik Dommisch ₁ , Arne S Schaefer ₁

Affiliation

The basis of phenotypic variation of periodontitis is genetic variability. Disease relevant effects of individual risk alleles are considered to result from genetic interactions. We investigated gene × gene (G×G) interactions of suggestive periodontitis susceptibility alleles.

中文翻译：

仅病例设计确定了 SIGLEC5 和 PLG 的遗传风险变异与 lncRNA CTD-2353F22.1 的相互作用，这暗示了牙周伤口愈合对疾病病因学的重要性

牙周炎表型变异的基础是遗传变异。个体风险等位基因的疾病相关影响被认为是由遗传相互作用引起的。我们研究了提示性牙周炎易感性等位基因的基因×基因（G×G）相互作用。

更新日期：2022-08-10

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