INTRODUCTION Peer victimization and aggression in adolescence are associated with later mental health morbidity. However, studies examining this association have not controlled for adolescent substance use. We aimed to study the associations between peer victimization, peer aggression, and mental disorders in adulthood, adjusting for substance use in adolescence. METHODS Participants were from the prospective Northern Finland Birth Cohort 1986. Data were available for 6682 individuals (70.8% of the original sample). Peer victimization and peer aggression were assessed with items from the Achenbach Youth Self Report at ages 15-16 years. Outcomes were nonorganic psychosis, anxiety disorder, mood disorder, substance use disorder, and any mental disorder (a none-vs-any indicator) at age 33 years collected from nationwide health care, insurance, and pension registers. Family structure, alcohol intoxication frequency, daily smoking, illicit drug use, and baseline psychopathology using Youth Self-Report total score, and parental mental disorders were considered as confounding factors. RESULTS In multivariable analyses, the association between peer victimization and psychosis (Hazard ratio [HR]: 2.9, 95% confidence interval [CI]: 1.2-6.9, p = .020) and mood disorder (HR: 1.7, 95% CI: 1.2-2.4, p = .012) in females remained significant after adjusting for confounders. Other associations between female and male peer victimization or aggression and the studied outcomes attenuated after adjustments. CONCLUSIONS Some associations between peer victimization and aggression and later mental health morbidity are explained by adolescent substance use. For females, substance use does not account for the increased risk of psychosis and mood disorder in those who experience peer victimization.

中文翻译：

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物质使用混淆了青春期同伴受害和攻击与成年期精神障碍之间的关联：一项前瞻性出生队列研究。

简介 青春期的同伴受害和攻击与后来的心理健康发病率有关。然而，检验这种关联的研究并未控制青少年物质使用。我们旨在研究成年期同伴受害、同伴攻击和精神障碍之间的关联，并根据青春期的物质使用进行调整。方法 参与者来自预期的 1986 年芬兰北部出生队列。数据可用于 6682 人（原始样本的 70.8%）。15-16 岁的阿亨巴赫青年自我报告中的项目评估了同伴受害和同伴攻击。结果是在 33 岁时从全国医疗保健、保险、和养老金登记册。家庭结构、酒精中毒频率、日常吸烟、非法药物使用和使用青少年自我报告总分的基线精神病理学以及父母精神障碍被认为是混杂因素。结果 在多变量分析中，同伴受害与精神病（风险比 [HR]：2.9，95% 置信区间 [CI]：1.2-6.9，p = .020）和情绪障碍（HR：1.7，95% CI： 1.2-2.4, p = .012) 在调整混杂因素后，女性仍然显着。女性和男性同伴受害或攻击与研究结果之间的其他关联在调整后减弱。结论 同伴受害和攻击以及后来的心理健康发病率之间的一些关联可以通过青少年物质使用来解释。对于女性来说，