A new biodegradable semi-interpenetrated polymer network (semi-IPN) of two US Food and Drug Administration approved materials, poly(3-hydroxybutyrate-co-3-valerate) (PHBV) and calcium alginate (CA) was engineered to provide an alternative strategy to enhance the poor adhesion properties of CA. The synthesis procedure allows the additional incorporation of 10 % w/w of graphene nanoplatelets (GNPs), which have no cytotoxic effect on human keratinocytes. This quantity of multilayer graphene provides superior antiviral activity to the novel semi-IPN against a surrogate virus of SARS-CoV-2. Adding GNPs hardly affects the water absorption or electrical conductivity of the pure components of CA and PHBV. However, the semi-IPN's electrical conductivity increases dramatically after adding GNP due to molecular rearrangements of the intertwined polymer chains that continuously distribute the GNP nanosheets, This new hydrophilic composite biomaterial film shows great promise for skin biomedical applications, especially those that require antiviral and/or biodegradable electroconductive materials.

一种由两种美国食品和药物管理局批准的材料聚（3-羟基丁酸-co -3-戊酸）（PHBV）和海藻酸钙（CA）组成的新型可生物降解半互穿聚合物网络（semi-IPN ）被设计用于提供替代方案增强 CA 不良粘附性能的策略。合成程序允许额外加入 10% w / w石墨烯纳米片 (GNP)，对人角质形成细胞没有细胞毒性作用。这种数量的多层石墨烯为新型半 IPN 提供了针对 SARS-CoV-2 替代病毒的卓越抗病毒活性。添加 GNPs 几乎不影响 CA 和 PHBV 纯组分的吸水率或电导率。然而，由于连续分布 GNP 纳米片的交织聚合物链的分子重排，添加 GNP 后半 IPN 的电导率急剧增加，这种新型亲水性复合生物材料薄膜显示出皮肤生物医学应用的巨大前景，特别是那些需要抗病毒和/或可生物降解的导电材料。