In England, all blood donations are screened in pools of 24 by nucleic acid test (NAT) for hepatitis E virus (HEV) RNA. During 2016–2020, this screening successfully identified and intercepted 1,727 RNA-positive donations. However, review of previous donations from infected platelet donors identified 9 donations in which HEV RNA detection was missed, of which 2 resulted in confirmed transmission: 1 infection resolved with ribavirin treatment, and 1 proceeded to fatal multiorgan failure within a month from infection. Residual risk calculations predict that over the 5-year study period, HEV RNA detection was missed by minipool NAT in 12–23 platelet and 177–354 whole-blood donations, but transmission risk remains undetermined. Although screening has been able to largely eliminate infectious HEV from the blood supply in England, missed detection of low levels of HEV RNA in donated blood can lead to a severe, even fulminant, infection in recipients and could be prevented by more sensitive screening.

在英格兰，所有献血者都通过核酸检测 (NAT) 对 24 人的血液池进行戊型肝炎病毒 (HEV) RNA 筛查。2016-2020 年间，该筛查成功识别并截获了 1,727 份 RNA 阳性捐赠物。然而，回顾受感染血小板捐赠者之前的捐赠，发现有 9 次捐赠遗漏了 HEV RNA 检测，其中 2 次确认传播：1 次感染通过利巴韦林治疗得到解决，1 次在感染后一个月内出现致命的多器官衰竭。残余风险计算预测，在 5 年的研究期间，12-23 例血小板和 177-354 例全血捐献中的小池 NAT 错过了 HEV RNA 检测，但传播风险仍未确定。尽管筛查已经能够在很大程度上消除英格兰血液供应中的传染性 HEV，