In the past 20 years, new insights into the genomic pathogenesis of prostate cancer have been provided. Large-scale integrative genomics approaches enabled researchers to characterize the genetic and epigenetic landscape of prostate cancer and to define different molecular subclasses based on the combination of genetic alterations, gene expression patterns and methylation profiles. Several molecular drivers of prostate cancer have been identified, some of which are different in men of different races. However, the extent to which genomics can explain racial disparities in prostate cancer outcomes is unclear. Future collaborative genomic studies overcoming the underrepresentation of non-white patients and other minority populations are essential.

在过去的 20 年中，人们对前列腺癌的基因组发病机制有了新的认识。大规模整合基因组学方法使研究人员能够描述前列腺癌的遗传和表观遗传景观，并根据遗传改变、基因表达模式和甲基化谱的组合定义不同的分子亚类。已经确定了几种前列腺癌的分子驱动因素，其中一些在不同种族的男性中是不同的。然而，基因组学可以在多大程度上解释前列腺癌结果中的种族差异尚不清楚。未来的协作基因组研究必须克服非白人患者和其他少数族裔人口代表性不足的问题。