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Pulmonary arterial wall thickness is increased in Behçet’s disease patients with major organ ınvolvement: Is it a sign of severity?
Rheumatology ( IF 4.7 ) Pub Date : 2022-08-09 , DOI: 10.1093/rheumatology/keac452
Seda Kutluğ Ağaçkıran 1 , Murat Sünbül 2 , Zekeriya Doğan 2 , Derya Kocakaya 3 , Semih Kayacı 3 , Haner Direskeneli 1 , Fatma Alibaz-Oner 1
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Objectives Behçet’s Disease (BD) is a unique systemic vasculitis mainly involving veins in contrast to other vasculitides. Prior studies showed that pulmonary arteries (PA) have a similar structure to systemic veins. In this study, we aimed to assess PA wall thickness by transthoracic echocardiography (TTE) in BD patients compared with healthy controls (HC) and patients with non-inflammatory pulmonary embolism (NIPE). Methods Patients with BD (n = 77), NIPE (n = 33) and HC (n = 57) were studied. PA wall thickness was measured from the mid-portion of the main PA with TTE by two cardiologists blinded to cases. Results PA wall thickness was significantly lower in HC (3.6 (0.3) mm) compared with NIPE (4.4 (0.5) mm) and BD (4.4 (0.6) mm) (p< 0.001 for both). PA wall thickness was similar between BD and NIPE (p= 0.6). Among patients with BD, PA wall thickness was significantly higher in patients with major organ involvement compared with mucocutaneous limited disease (4.7 (0.4) mm vs 3.7 (0.4) mm, p< 0.001), HC and NIPE (p< 0.001 and p= 0.006, respectively). PA wall thickness was comparable between patients with vascular and non-vascular major organ involvement (4.6 (0.5) mm vs 4.7 (0.3) mm, p= 0.3). Conclusion We observed that PA wall thickness was significantly higher in BD with major organ involvement compared with patients with only mucocutaneous limited disease, HC and NIPE. These results suggest that increased PA wall thickness may be a sign of severe disease with major organ involvement in BD.

中文翻译:

主要器官受累的白塞病患者肺动脉壁厚度增加:这是严重程度的标志吗?

目的 白塞氏病 (BD) 是一种独特的系统性血管炎,与其他血管炎不同,主要累及静脉。先前的研究表明,肺动脉 (PA) 具有与体静脉相似的结构。在这项研究中,我们旨在通过经胸超声心动图 (TTE) 评估 BD 患者与健康对照 (HC) 和非炎症性肺栓塞 (NIPE) 患者相比的肺动脉壁厚度。方法 研究了患有 BD (n = 77)、NIPE (n = 33) 和 HC (n = 57) 的患者。两名对病例不知情的心脏病专家用 TTE 从主 PA 的中部测量 PA 壁厚。结果 与 NIPE (4.4 (0.5) mm) 和 BD (4.4 (0.6) mm) 相比,HC (3.6 (0.3) mm) 中的 PA 壁厚显着降低(两者 p < 0.001)。BD 和 NIPE 之间的 PA 壁厚相似 (p = 0.6)。在 BD 患者中,与皮肤粘膜局限性疾病患者相比,主要器官受累患者的 PA 壁厚度显着更高(4.7 (0.4) mm 对 3.7 (0.4) mm,p < 0.001)、HC 和 NIPE(分别为 p < 0.001 和 p = 0.006)。PA 壁厚度在血管和非血管主要器官受累的患者之间具有可比性(4.6(0.5)mm 与 4.7(0.3)mm,p = 0.3)。结论 我们观察到,与仅患有粘膜皮肤局限性疾病、HC 和 NIPE 的患者相比,伴有主要器官受累的 BD 患者的 PA 壁厚度明显更高。这些结果表明,增加的 PA 壁厚度可能是 BD 中主要器官受累的严重疾病的征兆。HC和NIPE(分别为p<0.001和p=0.006)。PA 壁厚度在血管和非血管主要器官受累的患者之间具有可比性(4.6(0.5)mm 与 4.7(0.3)mm,p = 0.3)。结论 我们观察到,与仅患有粘膜皮肤局限性疾病、HC 和 NIPE 的患者相比,伴有主要器官受累的 BD 患者的 PA 壁厚度明显更高。这些结果表明,增加的 PA 壁厚度可能是 BD 中主要器官受累的严重疾病的征兆。HC和NIPE(分别为p<0.001和p=0.006)。PA 壁厚度在血管和非血管主要器官受累的患者之间具有可比性(4.6(0.5)mm 与 4.7(0.3)mm,p = 0.3)。结论 我们观察到,与仅患有粘膜皮肤局限性疾病、HC 和 NIPE 的患者相比,伴有主要器官受累的 BD 患者的 PA 壁厚度明显更高。这些结果表明,增加的 PA 壁厚度可能是 BD 中主要器官受累的严重疾病的征兆。结论 我们观察到,与仅患有粘膜皮肤局限性疾病、HC 和 NIPE 的患者相比,伴有主要器官受累的 BD 患者的 PA 壁厚度明显更高。这些结果表明,增加的 PA 壁厚度可能是 BD 中主要器官受累的严重疾病的征兆。结论 我们观察到,与仅患有粘膜皮肤局限性疾病、HC 和 NIPE 的患者相比,伴有主要器官受累的 BD 患者的 PA 壁厚度明显更高。这些结果表明,增加的 PA 壁厚度可能是 BD 中主要器官受累的严重疾病的征兆。
更新日期:2022-08-09
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