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Omicron BA.4/BA.5 escape neutralizing immunity elicited by BA.1 infection
Nature Communications ( IF 14.7 ) Pub Date : 2022-08-10 , DOI: 10.1038/s41467-022-32396-9
Khadija Khan 1, 2 , Farina Karim 1, 2 , Yashica Ganga 1 , Mallory Bernstein 1 , Zesuliwe Jule 1 , Kajal Reedoy 1 , Sandile Cele 1, 2 , Gila Lustig 3 , Daniel Amoako 4, 5 , Nicole Wolter 4, 6 , Natasha Samsunder 3 , Aida Sivro 3, 7 , James Emmanuel San 8 , Jennifer Giandhari 8 , Houriiyah Tegally 8, 9 , Sureshnee Pillay 8 , Yeshnee Naidoo 8 , Matilda Mazibuko 1 , Yoliswa Miya 1 , Nokuthula Ngcobo 1 , Nithendra Manickchund 10 , Nombulelo Magula 11 , Quarraisha Abdool Karim 3, 12 , Anne von Gottberg 4, 6 , Salim S Abdool Karim 3, 12 , Willem Hanekom 1, 13 , Bernadett I Gosnell 10 , , Richard J Lessells 8 , Tulio de Oliveira 8, 9, 14 , Mahomed-Yunus S Moosa 10 , Alex Sigal 1, 2, 3, 15
Affiliation  

SARS-CoV-2 Omicron (B.1.1.529) BA.4 and BA.5 sub-lineages, first detected in South Africa, have changes relative to Omicron BA.1 including substitutions in the spike receptor binding domain. Here we isolated live BA.4 and BA.5 viruses and measured BA.4/BA.5 neutralization elicited by BA.1 infection either in the absence or presence of previous vaccination as well as from vaccination without BA.1 infection. In BA.1-infected unvaccinated individuals, neutralization relative to BA.1 declines 7.6-fold for BA.4 and 7.5-fold for BA.5. In vaccinated individuals with subsequent BA.1 infection, neutralization relative to BA.1 decreases 3.2-fold for BA.4 and 2.6-fold for BA.5. The fold-drop versus ancestral virus neutralization in this group is 4.0-fold for BA.1, 12.9-fold for BA.4, and 10.3-fold for BA.5. In contrast, BA.4/BA.5 escape is similar to BA.1 in the absence of BA.1 elicited immunity: fold-drop relative to ancestral virus neutralization is 19.8-fold for BA.1, 19.6-fold for BA.4, and 20.9-fold for BA.5. These results show considerable escape of BA.4/BA.5 from BA.1 elicited immunity which is moderated with vaccination and may indicate that BA.4/BA.5 may have the strongest selective advantage in evading neutralization relative to BA.1 in unvaccinated, BA.1 infected individuals.



中文翻译:


Omicron BA.4/BA.5 逃避 BA.1 感染引起的中和免疫



SARS-CoV-2 Omicron (B.1.1.529) BA.4 和 BA.5 亚系首次在南非检测到,相对于 Omicron BA.1 发生了变化,包括刺突受体结合域的替换。在这里,我们分离了活的 BA.4 和 BA.5 病毒,并测量了在没有或存在先前疫苗接种的情况下以及在没有 BA.1 感染的情况下接种疫苗时由 BA.1 感染引起的 BA.4/BA.5 中和作用。在感染 BA.1 的未接种疫苗的个体中,相对于 BA.1,BA.4 的中和作用下降了 7.6 倍,BA.5 的中和作用下降了 7.5 倍。在随后感染 BA.1 的接种疫苗个体中,相对于 BA.1,BA.4 的中和作用降低了 3.2 倍,BA.5 的中和作用降低了 2.6 倍。该组中与祖先病毒中和相比,BA.1 的下降倍数为 4.0 倍,BA.4 为 12.9 倍,BA.5 为 10.3 倍。相反,在没有 BA.1 引发免疫的情况下,BA.4/BA.5 逃逸与 BA.1 相似:相对于祖先病毒中和的倍数下降,BA.1 为 19.8 倍,BA 为 19.6 倍。 4 倍,BA.5 的 20.9 倍。这些结果显示 BA.4/BA.5 从 BA.1 中大量逃逸,引发了免疫,这种免疫可通过疫苗接种来调节,并且可能表明 BA.4/BA.5 相对于 BA.1 在逃避中和方面可能具有最强的选择优势。未接种疫苗的 BA.1 感染者。

更新日期:2022-08-10
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