Herpes simplex virus lymphadenitis is associated with tumor reduction in a patient with chronic lymphocytic leukemia,The Journal of Clinical Investigation

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Herpes simplex virus lymphadenitis is associated with tumor reduction in a patient with chronic lymphocytic leukemia
The Journal of Clinical Investigation ( IF 15.9 ) Pub Date : 2022 , DOI: 10.1172/jci161109
Andres Chang _{1,

2} , Anton M Sholukh _{3,

4} , Andreas Wieland ₂ , David L Jaye ₅ , Mary Carrington _{6,

7} , Meei-Li Huang _{3,

4} , Hong Xie _{3,

4} , Keith R Jerome _{3,

4} , Pavitra Roychoudhury _{3,

4} , Alexander L Greninger _{3,

4} , Jean L Koff ₁ , Jonathon B Cohen ₁ , David M Koelle _{3,

4,

8,

9,

10} , Lawrence Corey _{3,

4,

8} , Christopher R Flowers ₁ , Rafi Ahmed ₂

Affiliation

Department of Hematology and Medical Oncology, Winship Cancer Institute and.
Emory Vaccine Center, Department of Microbiology and Immunology, Emory University School of Medicine Atlanta, Georgia, USA.
Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Departments of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA.
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Basic Science Program, Frederick National Laboratory for Cancer Research, and Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.
Ragon Institute of MGH, MIT and Harvard, Boston, Massachusetts, USA.
Department Medicine and.
Department of Global Health, University of Washington, Seattle, Washington, USA.
Department of Translational Immunology, Benaroya Research Institute, Seattle, Washington, USA.

Background. Herpes simplex virus lymphadenitis (HSVL) is an unusual presentation of HSV reactivation in patients with chronic lymphocytic leukemia (CLL) and is characterized by systemic symptoms and no herpetic lesions. The immune responses during HSVL have not, to our knowledge, been studied.

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