BACKGROUND Chronic obstructive pulmonary disease (COPD) and cardiovascular diseases are often comorbid conditions, their co-occurrence yields worse outcomes than either condition alone. This study aimed to investigate COPD impacts on the five-year prognosis of patients with coronary heart disease (CHD) after percutaneous coronary intervention (PCI). METHODS Patients with CHD who underwent PCI in 2013 were recruited, and divided into COPD group and non-COPD group. Adverse events occurring among those groups were recorded during the five-year follow-up period after PCI, including all-cause death and cardiogenic death, myocardial infarction, repeated revascularization, as well as stroke and bleeding events. Major adverse cardiac and cerebral events were a composite of all-cause death, myocardial infarction, repeated revascularization and stroke. RESULTS A total of 9843 patients were consecutively enrolled, of which 229 patients (2.3%) had COPD. Compared to non-COPD patients, COPD patients were older, along with poorer estimated glomerular filtration rate and lower left ventricular ejection fraction. Five-year follow-up results showed that incidences of all-cause death and cardiogenic death, as well as major adverse cardiac and cerebral events, for the COPD group were significantly higher than for non-COPD group (10.5% vs. 3.9%, 7.4% vs. 2.3%, and 30.1% vs. 22.6%, respectively). COPD was found under multivariate Cox regression analysis, adjusted for confounding factors, to be an independent predictor of all-cause death [odds ratio (OR) = 1.76, 95% CI: 1.15-2.70, P = 0.009] and cardiogenic death (OR = 2.02, 95% CI: 1.21-3.39, P = 0.007). CONCLUSIONS COPD is an independent predictive factor for clinical mortality, in which CHD patients with COPD are associated with worse prognosis than CHD patients with non-COPD.

中文翻译：

---

慢性阻塞性肺疾病对冠心病患者经皮冠状动脉介入治疗后远期预后的影响

背景技术慢性阻塞性肺病(COPD)和心血管疾病通常是共存疾病，它们的共同发生产生比单独的任何一种疾病更差的结果。本研究旨在探讨 COPD 对经皮冠状动脉介入治疗 (PCI) 后冠心病 (CHD) 患者五年预后的影响。方法招募2013年接受PCI的冠心病患者，分为COPD组和非COPD组。在 PCI 后的 5 年随访期间记录了这些组中发生的不良事件，包括全因死亡和心源性死亡、心肌梗死、重复血运重建以及中风和出血事件。主要的心脏和脑部不良事件是全因死亡、心肌梗死、反复血运重建和中风的复合事件。结果共连续入组9843例患者，其中COPD患者229例（2.3%）。与非 COPD 患者相比，COPD 患者年龄较大，估计肾小球滤过率较差，左心室射血分数较低。五年随访结果显示，COPD 组的全因死亡和心源性死亡以及主要心脑不良事件的发生率显着高于非 COPD 组（10.5% vs. 3.9%，分别为 7.4% 对 2.3% 和 30.1% 对 22.6%）。在多变量 Cox 回归分析中发现 COPD，调整了混杂因素，是全因死亡 [优势比 (OR) = 1.76, 95% CI: 1.15-2.70, P = 0.009] 和心源性死亡 (OR = 2.02, 95% CI: 1.21-3.39, P = 0.007)。