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Breadth and Dynamics of Human Norovirus-Specific Antibodies in the First Year of Life.
Journal of the Pediatric Infectious Diseases Society ( IF 2.5 ) Pub Date : 2022-10-25 , DOI: 10.1093/jpids/piac067
Nadja A Vielot 1 , Amanda Brinkman 2 , Christina DeMaso 2 , Samuel Vilchez 3 , Lisa C Lindesmith 4 , Filemon Bucardo 3 , Yaoska Reyes 3 , Ralph S Baric 4 , Elizabeth P Ryan 5 , Ralph Braun 2 , Sylvia Becker-Dreps 1, 4
Affiliation  

We measured antibody binding to diverse norovirus virus-like particles over 12 months in 16 children. All had maternal antibodies at 2 months, with estimated lowest levels at 5 months of age. Antibody increases after 3 months suggested natural infections. This information could guide the timing of future norovirus vaccines.

中文翻译:

生命第一年人类诺如病毒特异性抗体的广度和动态。

我们在 12 个月的时间里测量了 16 名儿童的抗体与多种诺如病毒病毒样颗粒的结合。所有人在 2 个月大时都有母体抗体,估计在 5 个月大时水平最低。3个月后抗体升高提示自然感染。该信息可以指导未来诺如病毒疫苗的上市时间。
更新日期:2022-07-18
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