A birth cohort design was used to understand whether heterotypic ligand-blocking norovirus antibodies provide cross-protection within the GII genogroup. We found that almost one-half of children who experienced a norovirus GII episode had preexisting antibodies heterotypic to the infecting genotype; therefore, these antibodies did not provide cross-protection.

中文翻译：

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预先存在的异型配体阻断抗体不能预防幼儿中的基因组 II 诺如病毒发作。

使用出生队列设计来了解异型配体阻断诺如病毒抗体是否在 GII 基因组内提供交叉保护。我们发现，几乎一半经历过诺如病毒 GII 感染的儿童体内预先存在与感染基因型异型的抗体；因此，这些抗体不提供交叉保护。