The treatment of hepatocellular carcinoma (HCC) has been transformed by the use of immune checkpoint inhibitors. However, most patients with HCC do not benefit from treatment with immunotherapy. There is an urgent need to understand the mechanisms that underlie response or resistance to immunotherapy for patients with HCC. The use of syngeneic mouse models that closely recapitulate the heterogeneity of human HCC will provide opportunities to examine the complex interactions between cancer cells and nonmalignant cells in the tumor microenvironment.

中文翻译：

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分析同基因小鼠 HCC 肿瘤模型作为了解抗 PD-1 敏感肿瘤微环境的框架

免疫检查点抑制剂的使用改变了肝细胞癌 (HCC) 的治疗方法。然而，大多数 HCC 患者无法从免疫疗法中获益。迫切需要了解 HCC 患者对免疫治疗反应或耐药的机制。使用密切概括人类 HCC 异质性的同系小鼠模型将为检查肿瘤微环境中癌细胞和非恶性细胞之间的复杂相互作用提供机会。