Gray Matter Volume Loss in Proposed Brain-First and Body-First Parkinson's Disease Subtypes,Movement Disorders

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Gray Matter Volume Loss in Proposed Brain-First and Body-First Parkinson's Disease Subtypes
Movement Disorders ( IF 7.4 ) Pub Date : 2022-08-09 , DOI: 10.1002/mds.29172
Magdalena Banwinkler ₁ , Verena Dzialas _{1,

2} , , Merle C Hoenig _{1,

3} , Thilo van Eimeren _{1,

4}

Affiliation

α-Synuclein pathology is associated with neuronal degeneration in Parkinson's disease (PD) and considered to sequentially spread across the brain (Braak stages). According to a new hypothesis of distinct α-synuclein spreading directions based on the initial site of pathology, the “brain-first” spreading subtype would be associated with a more asymmetric cerebral and nigrostriatal pathology than the “body-first” subtype.

中文翻译：

提出的大脑优先和身体优先帕金森病亚型中的灰质体积损失

α-突触核蛋白病理学与帕金森病 (PD) 中的神经元变性相关，并被认为会依次在大脑中扩散（Braak 阶段）。根据基于病理初始部位的不同 α-突触核蛋白扩散方向的新假设，与“身体优先”亚型相比，“脑优先”扩散亚型与更不对称的大脑和黑质纹状体病理学相关。

更新日期：2022-08-09

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