Hexokinase (HK)-1 mitochondrial-binding mechanisms and consequential physiological relevance remain unclear. Recently, De Jesus et al. studied myeloid cells with HK1 carrying mutated mitochondrial-binding domains (MBDs) and provided evidence that HK1 localization controls glucose metabolic fate. Increases in cytosolic HK1 may also contribute to the inflammation associated with diabetes and aging.

中文翻译：

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位置很重要：葡萄糖代谢和炎症中的己糖激酶 1

己糖激酶 (HK)-1 线粒体结合机制和相应的生理相关性仍不清楚。最近，德耶稣等人。研究了携带突变线粒体结合域 (MBD) 的 HK1 的骨髓细胞，并提供了 HK1 定位控制葡萄糖代谢命运的证据。细胞溶质 HK1 的增加也可能导致与糖尿病和衰老相关的炎症。