This paper presents a thorough biocompatibility evaluation of a CoCrMo medium entropy alloy to assess its potential to be utilized in orthopedic and dental implants. For this purpose, a wide range of systematic experiments were carried out, including static immersion, cell culture and radiation experiments. In particular, chemical biocompatibility and ion release behavior of the CoCrMo alloy were studied by carrying out static immersion experiments in artificial saliva (AS), simulated body fluid (SBF) and fetal bovine serum (FBS). Detailed analysis of the surfaces of the tested samples demonstrated that both passive oxide layer and hydroxyapatite formation occur on the CoCrMo sample surfaces immersed in AS, SBF and FBS for 28 days. The response of living cells to the CoCrMo alloy was tested utilizing cell culture experiments, and the evidence of Saos-2 cell viability and proliferation supported the static biocompatibility experiment results, indicating the potential of the CoCrMo alloy to be utilized as an orthopedic implant material. Finally, the effect of a CoCrMo implant on the actual radiation dose induced upon malignant tissue in the vicinity of the implant during a radiotherapy was evaluated by applying medical grade radiation to water phantoms circumventing CoCrMo samples. The results showed that the radiation accumulation in the tissue within the immediate vicinity of a CoCrMo implant would be a minimum, eliminating some of the undesired side effects. Overall, the results of the three different types of experiments reported in this paper have clearly demonstrated that the CoCrMo medium entropy alloy investigated in this study has significant potential to be utilized as a safe implant material in dental and orthopedic implants.

本文对 CoCrMo 中等熵合金进行了全面的生物相容性评估，以评估其在骨科和牙科植入物中的潜力。为此，进行了广泛的系统实验，包括静态浸泡、细胞培养和辐射实验。特别是通过在人工唾液（AS）、模拟体液（SBF）和胎牛血清（FBS）中进行静态浸泡实验，研究了CoCrMo合金的化学生物相容性和离子释放行为。对测试样品表面的详细分析表明，在浸入 AS、SBF 和 FBS 中 28 天的 CoCrMo 样品表面上发生了钝化氧化物层和羟基磷灰石的形成。利用细胞培养实验测试了活细胞对 CoCrMo 合金的反应，Saos-2 细胞活力和增殖的证据支持了静态生物相容性实验结果，表明 CoCrMo 合金具有用作骨科植入材料的潜力。最后，通过对绕过 CoCrMo 样品的水体模型应用医学级辐射，评估了 CoCrMo 植入物对放射治疗期间植入物附近恶性组织的实际辐射剂量的影响。结果表明，CoCrMo 植入物附近组织中的辐射积累将是最小的，从而消除了一些不希望的副作用。全面的，