Oxidized mitochondrial DNA (ox-mtDNA) activates NLRP3 inflammasome signaling through an ill-defined mechanism. In this issue of Immunity, Xian et al. reveal FEN1 endonuclease cleaves ox-mtDNA into fragments that escape mitochondria, igniting NLRP3 and cGAS-STING signaling and inflammation.

中文翻译：

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来吧mtDNA，点燃我的火

氧化的线粒体 DNA (ox-mtDNA) 通过不明确的机制激活 NLRP3 炎性体信号传导。在本期Immunity中，Xian 等人。揭示 FEN1 核酸内切酶将 ox-mtDNA 切割成逃离线粒体的片段，从而引发 NLRP3 和 cGAS-STING 信号传导和炎症。