Nanobiotechnology is a relatively unexplored area that has, nevertheless, shown relevant results in the fight against some diseases. Antimicrobial peptides (AMPs) are biomacromolecules with potential activity against multi/extensively drug-resistant bacteria, with a lower risk of generating bacterial resistance. They can be considered an excellent biotechnological alternative to conventional drugs. However, the application of several AMPs to biological systems is hampered by their poor stability and lifetime, inactivating them completely. Therefore, nanotechnology plays an important role in the development of new AMP-based drugs, protecting and carrying the bioactive to the target. This is the first review article on the different reported nanosystems using AMPs against bacteria listed on the WHO priority list. The current shortage of information implies a nanobiotechnological potential to obtain new drugs or repurpose drugs based on the AMP-drug synergistic effect.

纳米生物技术是一个相对未开发的领域，然而，在与某些疾病的斗争中显示出相关的结果。抗菌肽 (AMP) 是一种生物大分子，具有针对多重/广泛耐药细菌的潜在活性，产生细菌耐药性的风险较低。它们可以被认为是传统药物的优秀生物技术替代品。然而，几种 AMP 在生物系统中的应用受到它们较差的稳定性和寿命的阻碍，使它们完全失活。因此，纳米技术在开发新型 AMP 药物、保护生物活性并将其运载至靶点方面发挥着重要作用。这是第一篇关于使用 AMP 对抗 WHO 优先列表中细菌的不同报道纳米系统的评论文章。