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Raman studies of the adipose tissue: Current state-of-art and future perspectives in diagnostics
Progress in Lipid Research ( IF 14.0 ) Pub Date : 2022-08-09 , DOI: 10.1016/j.plipres.2022.101183
Krzysztof Czamara 1 , Zuzanna Majka 1 , Ewa Stanek 1 , Natalia Hachlica 2 , Agnieszka Kaczor 2
Affiliation  

The last decades revealed that the adipose tissue shows an unexplored therapeutic potential. In particular, targeting the perivascular adipose tissue (PVAT), that surrounds blood vessels, can prevent cardiovascular pathologies and browning of the adipose tissue can become an effective strategy against obesity. Therefore, new analytical tools are necessary to analyze this tissue. This review reports on the recent developments of various Raman-based techniques for the identification and quantification of the adipose tissue compared to conventional analytical methods. In particular, the emphasis is on analysis of PVAT, investigation of pathological changes of the adipose tissue in model systems and possibilities for its characterization in the clinical context. Overall, the review critically discusses the potential and limitations of Raman techniques in adipose tissue-targeted diagnostics and possible future anti-obesity therapies.



中文翻译:

脂肪组织的拉曼研究:诊断学的现状和未来展望

过去几十年表明,脂肪组织显示出未开发的治疗潜力。特别是,针对血管周围的血管周围脂肪组织 (PVAT) 可以预防心血管疾病,脂肪组织的褐变可以成为对抗肥胖的有效策略。因此,需要新的分析工具来分析这种组织。这篇综述报告了与传统分析方法相比,各种基于拉曼的脂肪组织识别和量化技术的最新发展。特别是,重点是分析 PVAT,研究模型系统中脂肪组织的病理变化及其在临床环境中表征的可能性。全面的,

更新日期:2022-08-13
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