Individuals with South Asian ancestry have a higher risk of heart disease than other groups but have been largely excluded from genetic research. Using data from 22,000 British Pakistani and Bangladeshi individuals with linked electronic health records from the Genes & Health cohort, we conducted genome-wide association studies of coronary artery disease and its key risk factors. Using power-adjusted transferability ratios, we found evidence for transferability for the majority of cardiometabolic loci powered to replicate. The performance of polygenic scores was high for lipids and blood pressure, but lower for BMI and coronary artery disease. Adding a polygenic score for coronary artery disease to clinical risk factors showed significant improvement in reclassification. In Mendelian randomisation using transferable loci as instruments, our findings were consistent with results in European-ancestry individuals. Taken together, trait-specific transferability of trait loci between populations is an important consideration with implications for risk prediction and causal inference.

具有南亚血统的人比其他群体患心脏病的风险更高，但基本上被排除在基因研究之外。我们利用来自基因与健康队列的 22,000 名英籍巴基斯坦人和孟加拉国人的数据以及关联的电子健康记录，对冠状动脉疾病及其关键危险因素进行了全基因组关联研究。使用功率调整的可转移性比率，我们发现了大多数有动力复制的心脏代谢基因座的可转移性的证据。血脂和血压的多基因评分表现较高，但体重指数和冠状动脉疾病的多基因评分较低。将冠状动脉疾病的多基因评分添加到临床危险因素中显示出重新分类的显着改善。在使用可转移基因座作为工具的孟德尔随机化中，我们的发现与欧洲血统个体的结果一致。总而言之，群体之间性状基因座的特定性状可转移性是一个重要的考虑因素，对风险预测和因果推断具有影响。