Abstract

Formaldehyde, one of the simplest reactive carbonyl substances, is involved in many physiological and pathological processes in living organisms. There is a large amount of data showing that abnormal elevation of formaldehyde is associated with a variety of diseases in the body, such as neurodegenerative diseases, Alzheimer's disease, cardiovascular diseases and cancer, and is also a representative carcinogen, so monitoring formaldehyde is of great importance for disease diagnosis and treatment. In this review, In this paper, we summarize and classify the last ten years of probes for the detection of formaldehyde according to different reaction mechanisms and discuss the structures and applications of the probes. Finally, we briefly describe the challenges and possible solutions in this field. We believe that more new probes provide powerful tools to study the function of formaldehyde in living systems.

 抽象的

甲醛是最简单的反应性羰基物质之一，参与生物体的许多生理和病理过程。大量数据表明，甲醛异常升高与体内多种疾病有关，如神经退行性疾病、阿尔茨海默病、心血管疾病和癌症等，也是代表性的致癌物质，因此监测甲醛具有重要意义。对于疾病的诊断和治疗具有重要意义。本文根据不同的反应机制对近十年来用于甲醛检测的探针进行了总结和分类，并讨论了探针的结构和应用。最后，我们简要描述了该领域的挑战和可能的解决方案。我们相信更多的新探针为研究甲醛在生命系统中的功能提供了强大的工具。