To show the feasibility of functional lung assessment by ¹⁹F MRI using low field (0.5 T) MRI scanner. One healthy volunteer participated in the studies. As a contrast for ¹⁹F pulmonary MRI, the gas mixture of 70% octafluorocyclobutane (OFCB) and 30% oxygen was used. ¹⁹F MR images of human lungs were obtained using 2D and 3D FSE methods. MRI data were used for volume reconstruction and for calculation of wash-in/-out and single-breath dynamics measurements. ¹⁹F 3D imaging provided information about gas distribution and lung volume assessment. The measured volume of the left and right parts of lungs were ≈1.7L and ≈1.8L, respectively. The wash-in/-out dynamics measurements determined that the effective time of gas washing in was 30 ± 5 s and washing out was 19 ± 4 s. Fractional ventilation was 29 ± 3% and 18 ± 2% for wash-in and wash-out processes, respectively. Dynamics of gas distribution during one breath cycle was analyzed. The calculated inspiration and expiration maps gave normalized effective times [rel. un.] for these stages- 0.95 ± 0.18 and 0.84 ± 0.15, respectively. Different ¹⁹F pulmonary MRI methods were implemented: 3D imaging, wash-in/-out dynamics and single respiratory cycle imaging. The results are agreed with known data and demonstrates possibility of ventilation assessment of the lungs at 0.5 Tesla.

使用低场 (0.5 T) MRI 扫描仪通过¹⁹ F MRI显示功能性肺评估的可行性。一名健康志愿者参加了研究。作为¹⁹ F 肺部 MRI 的对比，使用了 70% 八氟环丁烷 (OFCB) 和 30% 氧气的气体混合物。使用 2D 和 3D FSE 方法获得了人肺的^{19 F MR 图像。}MRI 数据用于容积重建和冲入/冲出和单次呼吸动力学测量的计算。¹⁹F 3D 成像提供了有关气体分布和肺容量评估的信息。左右肺的测量体积分别为≈1.7L和≈1.8L。洗入/洗出动力学测量确定气体洗入的有效时间为 30 ± 5 s，洗出的有效时间为 19 ± 4 s。冲入和冲出过程的分次通风分别为 29 ± 3% 和 18 ± 2%。分析了一次呼吸循环期间的气体分布动力学。计算得出的吸气和呼气图给出了归一化的有效时间 [rel. un.] 对于这些阶段，分别为 0.95 ± 0.18 和 0.84 ± 0.15。不同的¹⁹实施了 F 肺 MRI 方法：3D 成像、冲洗/冲洗动力学和单呼吸周期成像。结果与已知数据一致，并证明了在 0.5 特斯拉时对肺部进行通气评估的可能性。