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Ventilation Study of the Human Lungs by 19F MRI at 0.5 Tesla
Applied Magnetic Resonance ( IF 1.1 ) Pub Date : 2022-08-09 , DOI: 10.1007/s00723-022-01488-6
Olga S. Pavlova , Nikolay V. Anisimov , Mikhail V. Gulyaev , Lev L. Gervits , Yury A. Pirogov

To show the feasibility of functional lung assessment by 19F MRI using low field (0.5 T) MRI scanner. One healthy volunteer participated in the studies. As a contrast for 19F pulmonary MRI, the gas mixture of 70% octafluorocyclobutane (OFCB) and 30% oxygen was used. 19F MR images of human lungs were obtained using 2D and 3D FSE methods. MRI data were used for volume reconstruction and for calculation of wash-in/-out and single-breath dynamics measurements. 19F 3D imaging provided information about gas distribution and lung volume assessment. The measured volume of the left and right parts of lungs were ≈1.7L and ≈1.8L, respectively. The wash-in/-out dynamics measurements determined that the effective time of gas washing in was 30 ± 5 s and washing out was 19 ± 4 s. Fractional ventilation was 29 ± 3% and 18 ± 2% for wash-in and wash-out processes, respectively. Dynamics of gas distribution during one breath cycle was analyzed. The calculated inspiration and expiration maps gave normalized effective times [rel. un.] for these stages- 0.95 ± 0.18 and 0.84 ± 0.15, respectively. Different 19F pulmonary MRI methods were implemented: 3D imaging, wash-in/-out dynamics and single respiratory cycle imaging. The results are agreed with known data and demonstrates possibility of ventilation assessment of the lungs at 0.5 Tesla.



中文翻译:

通过 19F MRI 在 0.5 特斯拉下对人体肺部的通气研究

使用低场 (0.5 T) MRI 扫描仪通过19 F MRI显示功能性肺评估的可行性。一名健康志愿者参加了研究。作为19 F 肺部 MRI 的对比,使用了 70% 八氟环丁烷 (OFCB) 和 30% 氧气的气体混合物。使用 2D 和 3D FSE 方法获得了人肺的19 F MR 图像。MRI 数据用于容积重建和冲入/冲出和单次呼吸动力学测量的计算。19F 3D 成像提供了有关气体分布和肺容量评估的信息。左右肺的测量体积分别为≈1.7L和≈1.8L。洗入/洗出动力学测量确定气体洗入的有效时间为 30 ± 5 s,洗出的有效时间为 19 ± 4 s。冲入和冲出过程的分次通风分别为 29 ± 3% 和 18 ± 2%。分析了一次呼吸循环期间的气体分布动力学。计算得出的吸气和呼气图给出了归一化的有效时间 [rel. un.] 对于这些阶段,分别为 0.95 ± 0.18 和 0.84 ± 0.15。不同的19实施了 F 肺 MRI 方法:3D 成像、冲洗/冲洗动力学和单呼吸周期成像。结果与已知数据一致,并证明了在 0.5 特斯拉时对肺部进行通气评估的可能性。

更新日期:2022-08-09
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